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Microsomal Triglyceride Transfer Protein

MTTP

MTTP Gene

The MTTP gene provides instructions for making a protein called microsomal triglyceride transfer protein. The microsomal triglyceride transfer protein helps produce beta-lipoproteins, which are molecules that consist of proteins combined with cholesterol and particular fats called triglycerides.

These beta-lipoproteins contain apolipoprotein B and are critical for the creation of molecules called chylomicrons, which are formed when dietary fats and cholesterol are absorbed through the intestines. The absorption of dietary fat via chylomicrons is also necessary for the absorption of certain fat-soluble vitamins, especially vitamins E, A, and sometimes K. Other beta-lipoproteins containing apolipoprotein B, particularly low-density lipoproteins (LDL) and very low-density lipoproteins (VLDL), are created by microsomal triglyceride transfer protein in the liver. The lipoproteins transport fats, cholesterol, and fat-soluble vitamins throughout the body by way of the bloodstream.  

Sufficient levels of fats, cholesterol, and vitamins are necessary for normal growth, development, and maintenance of the body's cells and tissues, particularly nerve cells and tissues in the eye.

Mutations in the MTTP gene cause abetalipoproteinemia

 
 

 

 

 

 

MTTP

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