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PEPTIC ULCER DISEASE

About the Author

Dr. Minocha (http://www.diagnosishealth.com/minocha.htm) is the Professor of Medicine and Director, Division of Digestive Diseases at the University of Mississippi Medical Center in Jackson, MS, and is the author of How to Stop Heartburn; Simple Ways to Heal Heartburn and Acid Reflux. Read Daily Stomach Ulcer Peptic Ulcer  Health News/Tips Here

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whatnow1.wmf (11702 bytes)What is peptic ulcer disease (PUD)? The term PUD generally refers to spectrum of disorders that includes gastric ulcer (GU), pyloric channel ulcer, duodenal ulcer (DU) and postoperative ulcers at or near the site of surgical anastomosis.

 

meeting.wmf (4950 bytes)HISTORICAL PERSPECTIVE

Looking back at history, peptic ulcer was a rare and generally unrecognized as a cause of symptoms/complications or death until the early 19th century. Despite sporadic case reports beginning in late 18th century, Peptic Ulcer Disease did not become widely appreciated until early 20th century. The first 6 decades saw the dominance of surgery in the treatment of peptic ulcer. With the introduction of acid suppressive drugs like histamine-2 blockers in 1970s, the treatment of PUD was revolutionized. By nineteen eighties, the advent of Helicobacter pylori (HP) brought about a dramatic twist and possibly the cure.

 

CAUSES OF PEPTIC ULCER DISEASE

 

 

 

examine.wmf (7542 bytes)DIAGNOSIS OF PEPTIC ULCER DISEASE

 

 

 

 

HM00213_.wmf (24978 bytes)TREATMENT OF PEPTIC ULCER DISEASE

 

 

arrows3.wmf (2454 bytes)HEALING AND RELAPSE

 

BS01001_.wmf (2720 bytes)PREVENTION OF RELAPSE

 

NA00723_.wmf (56700 bytes)TREATMENT OF Helicobacter Pylori (HP)

  • HP tends to be a very resistant bug not easily amenable to treatment. Although HP shows in vitro sensitivity to most antibiotics, it does not translate in to in vivo efficacy. Women and immigrants from developing countries tend to have higher incidence of resistant HP. A number of recipes involving different drug combinations are available but very few have actually been approved by the FDA. There is as yet no consensus about specific regimens. The gold standard is a triple drug regimen consisting of Bismuth, metronidazole and Amoxicillin or tetracycline for two wks achieving an eradication rate of 90%. In order to improve compliance, two drug regimens have been developed. They involve combination of proton pump inhibitor (PPI) and a antibiotic.

 
 

MERITS OF Helicobacter Pylori  (HP) ERADICATION

 

PE00168_.wmf (2284 bytes)ROLE OF SURGERY IN PEPTIC ULCER DISEASE 

 

 

checkmrk.wmf (758 bytes)CONCLUSION

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